Emilie Arnault, et al.
PLOS ONE
August 2013
Key points:
- Our results defined the precise spectrum of light retinal toxicity in physiological irradiance conditions on an in vitro model of age-related macular degeneration
- A2E was found to be a photosensitizer triggering cell death in human RPE cells
- results suggest that the 415–455 nm spectral range may be the most damaging light for patients at risk for ARMD.
- Our result suggests that filtering light in a narrower band from 415 nm to 455 nm may be sufficient to prevent or limit the AMD disease development or progression.