Retina

These studies evaluate the potential to of blue light to damage photoreceptor cells and other structures in the retina, which could  cause permanent vision loss.

 

 

2019


Mitochondria as Potential Targets and Initiators of the Blue Light Hazard to the Retina.

J.-X. Tao, W.-C. Zhou and X.-G. Zhu, Oxidative medicine and cellular longevity, 2019. 2019: p. 6435364-6435364. https://doi.org/10.1155/2019/6435364

 


Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila.

T.R. Nash, E.S. Chow, A.D. Law, S.D. Fu, et al., npj Aging and Mechanisms of Disease, 2019. 5(1): p. 8. https://doi.org/10.1038/s41514-019-0038-6

 


The Protective Effects of Blue Light-Blocking Films With Different Shielding Rates: A Rat Model Study.

X. Liu, Q. Zhou, H. Lin, J. Wu, et al., Trans Vis Sci Tech. , 2019. 8(3): p. 1-11. https://doi.org/10.1167/tvst.8.3.19

 


Effects of the Emitted Light Spectrum of Liquid Crystal Displays on Light-Induced Retinal Photoreceptor Cell Damage.

C.-W. Lin, C.-M. Yang and C.-H. Yang, International journal of molecular sciences, 2019. 20(9): p. 2318. https://doi.org/10.3390/ijms20092318

 


Retinal Neuron Is More Sensitive to Blue Light-Induced Damage than Glia Cell Due to DNA Double-Strand Breaks. 

P. Chen, Z. Lai, Y. Wu, L. Xu, et al., Cells, 2019. 8(2073-4409 (Print)). https://doi.org/10.3390/cells8010068

 


Oxidative Stress in Retinal Degeneration Promoted by Constant LED Light.

M.M. Benedetto and M.A. Contin, Frontiers in Cellular Neuroscience, 2019. 13: p. 139. https://doi.org/10.3389/fncel.2019.00139

 


 

 

2018


Removal of the blue component of light significantly decreases retinal damage after high intensity exposure.

J. Vicente-Tejedor, M. Marchena, L. Ramírez, D. García-Ayuso, et al., PLOS ONE, 2018. 13(3): p. e0194218. https://doi.org/10.1371/journal.pone.0194218

 


What We Know About the Epidemiology of Dry Eye Disease in JapanEpidemiology of Dry Eye Disease in Japan.

M. Uchino, Investigative Ophthalmology & Visual Science, 2018. 59(14): p. DES1-DES6. https://doi.org/10.1167/iovs.17-23491

 


Digital eye strain: prevalence, measurement and amelioration.

A.L.W. Sheppard, James S., BMJ Open Ophthalmology, 2018. 3(1). http://bmjophth.bmj.com/content/3/1/e000146.abstract

 


Blue light excited retinal intercepts cellular signaling.

K. Ratnayake, John L.Lakmal, O. HarshanaKarunarathne, Ajith, Scientific Reports, 2018. 8(1): p. 10207. https://doi.org/10.1038/s41598-018-28254-8

 


Blue Light Hazard: are exposure limit values protective enough for newborn infants?

S. Point, Radioprotection, 2018. 53(3): p. 219-224. https://doi.org/10.1051/radiopro/2018025

 


Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions.

V. Marek, S. Mélik-Parsadaniantz, T. Villette, F. Montoya, et al., Free Radical Biology and Medicine, 2018. 126: p. 27-40. https://doi.org/10.1016/j.freeradbiomed.2018.07.012

 


LED Illumination – A Hazard to the Eye?

M. Hessling, P.S. Koelbl and C. Lingenfelder, Optik & Photonik, 2018. 13(4): p. 40-44. https://doi.org/10.1002/opph.201800029

 


Warding off the blues.

B. Hefner, Review of Optometry, 2018. 155(6): p. 71-78. https://www.reviewsce.com/ce/warding-off-the-blues

 


Blue-blocking spectacles lenses for retinal damage protection and circadian rhythm: evaluation parameters.

R. Comparetto and A. Farini, arXiv:1806.04751 [q-bio.OT], 2018. https://arxiv.org/abs/1806.04751

 


Ocular Tolerance of Contemporary Electronic Display Devices.

A.J.Y. Clark, P.Khaderi, K. R.Moshfeghi, A. A., Ophthalmic Surg Lasers Imaging Retina, 2018. 49(5): p. 346-354. https://doi.org/10.3928/23258160-20180501-08

 


 

 

2017


Effects of white light-emitting diode (LED) exposure on retinal pigment epithelium in vivo.

I. Jaadane, G.E. Villalpando Rodriguez, P. Boulenguez, S. Chahory, et al., Journal of Cellular and Molecular Medicine, 2017. 21(12): p. 3453-3466. https://doi.org/10.1111/jcmm.13255

 


Editor’s Highlight: Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis.

H.-W. Cheng, M.-R. Wu, S.-H. Huang, C.-H. Lin, et al., Toxicological Sciences, 2017. 157(1): p. 196-210. https://doi.org/10.1093/toxsci/kfx030

 


 

 

2016


How safe is the light during ophthalmic diagnosis and surgery.

M. Wolffe, Eye (London, England), 2016. 30(2): p. 186-188. https://doi.org/10.1038/eye.2015.247

 


Light damage to the retina: an historical approach.

D. van Norren and J.J. Vos, Eye (London, England), 2016. 30(2): p. 169-172. https://doi.org/10.1038/eye.2015.218

 


Effects of blue light on the circadian system and eye physiology.

G. Tosini, I. Ferguson and K. Tsubota, Molecular Vision 2016. 22(2157-2518): p. 61-72. http://www.molvis.org/molvis/v22/61

 


Retinal Light Damage Through Prolonged Visible Light Exposure.

T. Reiter, EC Ophthalmology, 2016. 4.3: p. 517-521. https://www.ecronicon.com/ecop/pdf/ECOP-04-000091.pdf

 


Exploring Clinical Evidence and the Benefits of Filtering Out Harmful Light

F. Loperfido and A. Marchese, in Points de Vue – International Review of Ophthalmic Optics. 2016, Essilor International. www.pointsdevue.com

 


Relationship between Oxidative Stress, Circadian Rhythms, and AMD.

M.L. Fanjul-Moles and G.O. Lopez-Riquelme, Oxidative Medicine and Cellular Longevity, 2016. 2016: p. 18. https://doi.org/10.1155/2016/7420637

 


Light pollution: the possible consequences of excessive illumination on retina.

M.A. Contin, M.M. Benedetto, M.L. Quinteros-Quintana and M.E. Guido, Eye (Lond). , 2016. 30(2): p. 255–263. https://doi.org/10.1038/eye.2015.221

 


 

 

2015


Retinal damage induced by commercial light emitting diodes (LEDs).

I. Jaadane, P. Boulenguez, S. Chahory, S. Carré, et al., Free Radical Biology and Medicine, 2015. 84: p. 373-384. https://doi.org/10.1016/j.freeradbiomed.2015.03.034

 


Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina.

P.B. Geiger, M; Grimm, C; Samardzija, M, Cell death & disease, 2015. 6(11): p. e1985. https://doi.org/10.1038/cddis.2015.333

 


The 11-cis Retinal Origins of Lipofuscin in the Retina.

L. Adler, N.P. Boyer, C. Chen, Z. Ablonczy, et al., Progress in Molecular Biology and Translational Science, 2015. 134: p. e1-e12. https://doi.org/10.1016/bs.pmbts.2015.07.022

 


 

 

2014


What optometrists need to know about IpRGCs and why.

H. RE., Optom Vis Perf 2014. 2(4): p. 364-374. https://www.niwotvision.com/articles/IpRGC-article.pdf

 


The effect of visual blue light on mitochondrial function associated with retinal ganglions cells.

N.N. Osborne, C. Nunez-Alvarez and S. Del Olmo-Aguado, Experimental Eye Research, 2014. 128: p. 8-14. http://dx.doi.org/10.1016/j.exer.2014.08.012

 


Hidden Blue Hazard? LED Lighting and Retinal Damage in Rats.

T. Lougheed, Environmental Health Perspectives, 2014. 122(3): p. A81-A81. https://doi.org/10.1289/ehp.122-A81

 


Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light.

Y. Kuse, K. Ogawa, K. Tsuruma, M. Shimazawa, et al., Scientific Reports, 2014. 4: p. 5223. https://doi.org/10.1038/srep05223

 


Blue Light and Eye Damage.

G.W. Good. 2014, American optometric Association. https://www.aoa.org/Documents/CRG/Blue%20Light%20and%20Eye%20Damage.pdf

 


 

 

2013


Bad Blue, Good Blue, Eye and Vision

T. Villette, Points de Vue – International Review of Ophthalmic Optics online publication, 2013. 68: p. 7-8. www.pointsdevue.com

 


Macular pigment and its contribution to vision.

E. Loskutova, J. Nolan, A. Howard and S. Beatty, Nutrients, 2013. 5(6): p. 1962-1969. https://doi.org/10.3390/nu5061962

 


Photoprotective Effects of Blue Light Absorbing Filter against LED Light Exposure on Human Retinal Pigment Epithelial Cells In Vitro.

E. Chamorro, S. Carralero, C. Bonnin-Arias, M. Pérez-Carrasco, et al., J Carcinog Mutagen, 2013. S6: p. 8. https://dx.doi.org/10.4172/2157-2518.S6-008

 


Effects of light-emitting diode radiations on human retinal pigment epithelial cells in vitro.

E. Chamorro, C. Bonnin-Arias, M.J. Perez-Carrasco, J. Munoz de Luna, et al., Photochem Photobiol, 2013. 89(2): p. 468-73. https://doi.org/10.1111/j.1751-1097.2012.01237.x

 


Phototoxic Action Spectrum on a Retinal Pigment Epithelium Model of Age-Related Macular Degeneration Exposed to Sunlight Normalized Conditions.

E. Arnault, C. Barrau, C. Nanteau, P. Gondouin, et al., PLOS ONE, 2013. 8(8): p. e71398. https://doi.org/10.1371/journal.pone.0071398

 


 

 

2012


The susceptibility of the retina to photochemical damage from visible light.

J.J. Hunter, J.I. Morgan, W.H. Merigan, D.H. Sliney, et al., Prog Retin Eye Res, 2012. 31(1): p. 28-42. https://doi.org/10.1016/j.preteyeres.2011.11.001

 


Personal risks posed by LEDs used in everyday devices.

E. Chamorro, C. Bonnin, L.L. Lobato-Rincón, J.J. Navarro-Valls, et al., Seguridad y Medio Ambiente – N128, 2012. 32(N128): p. 1-7. http://www.mapfre.com/fundacion/html/revistas/seguridad/n128/en/article3.html

 


Lipofuscin and N-Retinylidene-N-Retinylethanolamine (A2E) Accumulate in Retinal Pigment Epithelium in Absence of Light Exposure: their Origin is 11-cis-retinal.

N.P. Boyer, D. Higbee, M.B. Currin, L.R. Blakeley, et al., J. Biol. Chem., 2012. 287(26): p. 22276-22286. https://doi.org/10.1074/jbc.M111.329235

 


 

 

2011


Light-emitting diodes (LED) for domestic lighting: Any risks for the eye?

F. Behar-Cohen, C. Martinsons, F. Viénot, G. Zissis, et al., Progress in Retinal and Eye Research, 2011. 30(4): p. 239-257. https://doi.org/10.1016/j.preteyeres.2011.04.002

 


 

 

2010


Retinal light toxicity.

P.N. Youssef, N. Sheibani and D.M. Albert, Eye, 2010. 25: p. 1. https://doi.org/10.1038/eye.2010.149

 


Retinal light damage: Mechanisms and protection.

D.T. Organisciak and D.K. Vaughan, Progress in Retinal and Eye Research, 2010. 29(2): p. 113-134. https://doi.org/10.1016/j.preteyeres.2009.11.004

 


 

 

2009


Light-Induced Damage to the Retina.

M. Rozanowska, B. Rozanowski and M. Boulton. 2009  [cited A ccess 2009; Available from:  http://photobiology.info/Rozanowska.html.

 


 

 

2008


Macular pigment in the human retina: histological evaluation of localization and distribution.

M. Trieschmann, F.J.G.M. van Kuijk, R. Alexander, P. Hermans, et al., Eye, 2008. 22(1): p. 132-137. https://doi.org/10.1038/sj.eye.6702780

 


 

 

2007


Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina.

F.H. Zaidi, J.T. Hull, Stuart N. Peirson, K. Wulff, et al., Current Biology, 2007. 17(24): p. 2122-2128. https://doi.org/10.1016/j.cub.2007.11.034

 


 

 

2006


Photochemical Damage of the Retina.

J. Wu, S. Seregard and P.V. Algvere, Survey of Ophthalmology, 2006. 51(5): p. 461-481. https://doi.org/10.1016/j.survophthal.2006.06.009

 


Blocking the blue.

P. Hawse, The British journal of ophthalmology, 2006. 90(8): p. 939-940. https://doi.org/10.1136/bjo.2006.095653

 


Age-related maculopathy and the impact of blue light hazard.

P.V. Algvere, J. Marshall and S. Seregard, Acta Ophthalmologica Scandinavica, 2006. 84(1): p. 4-15. https://doi.org/10.1111/j.1600-0420.2005.00627.x

 


 

 

2005


Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration.

A. Wenzel, C. Grimm, M. Samardzija and C.E. Remé, Progress in retinal and eye research, 2005. 24(2): p. 275-306. https://doi.org/10.1016/j.preteyeres.2004.08.002

 


Blue Light Induces Mitochondrial DNA Damage and Free Radical Production in Epithelial Cells.

B.F. Godley, F.A. Shamsi, F.-Q. Liang, S.G. Jarrett, et al., 2005. 280(22): p. 21061-21066. https://doi.org/10.1074/jbc.M502194200

 


 

 

2004


A model of spectral filtering to reduce photochemical damage in age-related macular degeneration

S.M. Meyers, M.A. Ostrovsky and R.F. Bonner, Trans Am Ophthalmol Soc, 2004. 102: p. 83-95. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280090/

 


 

 

2000


The Lipofuscin Fluorophore A2E Mediates Blue Light– Induced Damage to Retinal Pigmented Epithelial Cells.

J.R. Sparrow, K. Nakanishi and C.A. Parish, Invest Ophthalmol Vis Sci. , 2000. 41: p. 1981–1989. https://iovs.arvojournals.org/article.aspx?articleid=2123554

 


 

 

1999


Blue light induced apoptosis in rat retina.

J. Wu, S. Seregard, B. Spångberg, M. Oskarsson, et al., Eye, 1999. 13: p. 577. https://doi.org/10.1038/eye.1999.142

 


 

 

1006


Light damage revisited: converging evidence, diverging views?

C. Remé, J. Reinboth, M. Clausen and F. Hafezi, Graefe’s Archive for Clinical and Experimental Ophthalmology, 1996. 234(1): p. 2-11. https://doi.org/10.1007/BF00186512

 


 

 

1084


Quantifying retinal irradiance levels in light damage experiments.

D.H. Sliney, Current Eye Research, 1984. 3(1): p. 175-179. https://doi.org/10.3109/02713688408997199

 


 

 

1981


Additivity and repair of actinic retinal lesions.

G.A. Griess and M.F. Blankenstein, Investigative Ophthalmology & Visual Science, 1981. 20(6): p. 803-807. https://iovs.arvojournals.org/article.aspx?articleid=2176197

 


 

 

1980


The nature of retinal radiation damage: Dependence on wavelength, power level and exposure time.

W.T. Ham, J.J. Ruffolo, H.A. Mueller and D. Guerry, Vision Research, 1980. 20(12): p. 1105-1111. https://doi.org/10.1016/0042-6989(80)90047-4

 


Retinal light exposure from ophthalmoscopes, slit lamps, and overhead surgical lamps. An analysis of potential hazards.

J.L. Calkins and B.F. Hochheimer, Investigative Ophthalmology & Visual Science, 1980. 19(9): p. 1009-1015. https://iovs.arvojournals.org/article.aspx?articleid=2159022

 


 

 

1979


Sensitivity of the retina to radiation damage as a function of wavelength.

W.T. Ham, H.A. Mueller, J.J. Ruffolo and A.M. Clarke, Photochemistry and Photobiology, 1979. 29: p. 735-743. https://doi.org/10.1111/j.1751-1097.1979.tb07759.x